abstract：:The growing popularity of zebrafish in psychopharmacology and behavioral brain research is partly due to the practicality and simplicity of drug administration in this species. Several drugs may be administered to zebrafish by immersing the fish in the drug solution. Furthermore, numerous drugs developed for mammals, ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Zahid H,Tsang B,Ahmed H,Lee RCY,Tran S,Gerlai R

更新日期：2018-04-20 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is characterized by impairments in mnestic functions, especially in the domain of episodic memory. These alterations might affect different aspects of episodic memory functioning. Here we tested PTSD patients and healthy controls (matched for age, sex and education) in a newly dev...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Zlomuzica A,Woud ML,Machulska A,Kleimt K,Dietrich L,Wolf OT,Assion HJ,Huston JP,De Souza Silva MA,Dere E,Margraf J

更新日期：2018-04-20 00:00:00

abstract：:Nicotine consumption through smoking affects anxious states in humans. However, the precise role of nicotinic acetylcholine receptor (nAChR) circuitry in the regulation of anxiety remains elusive. The Lynx protein Lypd6 is highly enriched in synaptic loci and has been previously identified as an endogenous inhibitor o...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Arvaniti M,Polli FS,Kohlmeier KA,Thomsen MS,Andreasen JT

更新日期：2018-03-02 00:00:00

abstract：:Human societies demand of its composing members the development of a wide array of social tools and strategies. A notable example is human outstanding ability to cooperate with others, in all its complex forms, depicting the reality of a highly demanding social framework in which humans need to be integrated as to att...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Soares MC,Cardoso SC,Carvalho TDS,Maximino C

更新日期：2018-03-02 00:00:00

abstract：OBJECTIVES:Both peripheral and central brain-derived neurotrophic factor (BDNF) levels are decreased in depression and normalized by efficient anti-depressive therapies. While depression symptoms are frequent in rheumatoid arthritis, BDNF has been poorly investigated in this pathology. Therefore, the present study expl...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pedard M,Demougeot C,Prati C,Marie C

更新日期：2018-03-02 00:00:00

abstract：BACKGROUND:The single nucleotide polymorphism (SNP) rs1344706 [A>C] within intron 2 of the zinc finger protein 804A gene (ZNF804A) is associated with schizophrenia at the genome-wide level, but its function in relation to the development of psychotic disorders, including its influence on brain morphology remains unclea...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Quidé Y,Matosin N,Atkins JR,Fitzsimmons C,Cairns MJ,Carr VJ,Australian Schizophrenia Research Bank (ASRB).,Green MJ

更新日期：2018-03-02 00:00:00

abstract：BACKGROUND:Cannabis is one of the most widely-used drugs in industrialized countries. It is now well established that cannabis use impacts neurocognition. In the intoxication period time episodic memory, working memory and attention are impacted and impulsivity is increased. The long-term effects of cannabis use tend t...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Cosker E,Schwitzer T,Ramoz N,Ligier F,Lalanne L,Gorwood P,Schwan R,Laprévote V

更新日期：2018-03-02 00:00:00

abstract：:The identification of key genes in transcriptomic data constitutes a huge challenge. Our review of microarray reports revealed 88 genes whose transcription is consistently regulated by glucocorticoids (GCs), such as cortisol, corticosterone and dexamethasone, in the brain. Replicable transcriptomic data were combined ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Juszczak GR,Stankiewicz AM

更新日期：2018-03-02 00:00:00

abstract：:Spinophilin is a multifunctional scaffold protein that regulates the formation and function of dendritic spines and plays a role in neuronal migration. The distinct roles of spinophilin depend on its localization and the direct interaction with other proteins, which may target spinophilin to specific locations within ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Brocos-Mosquera I,Nuñez Del Moral A,Morentin B,Meana JJ,Callado LF,Erdozain AM

更新日期：2018-02-02 00:00:00

abstract：BACKGROUND:Human brain is a topologically complex network embedded in anatomical space, and anatomical distance may affect functional connectivity (FC) in schizophrenia. However, little is known if and how this effect occurs in adolescent-onset schizophrenia (AOS). METHODS:We explored long- and short-range FC through ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wang S,Zhan Y,Zhang Y,Lyu L,Lyu H,Wang G,Wu R,Zhao J,Guo W

更新日期：2018-02-02 00:00:00

abstract：:A candidate gene and a genome-wide approach were combined to study the pharmacogenetics of antidepressant response and resistance. Investigated genes were selected on the basis of pleiotropic effect across psychiatric phenotypes in previous genome-wide association studies and involvement in antidepressant response. Th...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Fabbri C,Corponi F,Albani D,Raimondi I,Forloni G,Schruers K,Kasper S,Kautzky A,Zohar J,Souery D,Montgomery S,Cristalli CP,Mantovani V,Mendlewicz J,Serretti A

更新日期：2018-02-02 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated brain gray matter reduction in methamphetamine (MA) users; however, little is known about longitudinal brain structural alternations during abstinence. METHOD:Brain volumes were compared among 30 MA-dependent patients (average 6.3years of drug use) at 6months' abstinence a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ruan X,Zhong N,Yang Z,Fan X,Zhuang W,Du J,Jiang H,Zhao M

更新日期：2018-02-02 00:00:00

abstract：:People with Huntington's disease (HD) exhibit altered processing of emotional information, especially disgust and other negative emotions. These impairments are likely due to the effects of the disease on underlying brain networks. We examined whether oxytocin, when given intranasally, would normalise aberrant brain r...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Labuschagne I,Poudel G,Kordsachia C,Wu Q,Thomson H,Georgiou-Karistianis N,Stout JC

更新日期：2018-02-02 00:00:00

abstract：:The effect of antidepressant drugs on tumor progress is very poorly recognized. The aim of the present study was to examine the effect of individual reactivity to stress and 24-day desipramine (DES) administration on the metastatic colonization of adenocarcinoma MADB 106 cells in the lungs of Wistar rats. Wistar rats ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Grygier B,Kubera M,Wrona D,Roman A,Basta-Kaim A,Gruca P,Papp M,Rogoz Z,Leskiewicz M,Budziszewska B,Regulska M,Korzeniak B,Curzytek K,Glombik K,Slusarczyk J,Maes M,Lason W

更新日期：2018-01-03 00:00:00

abstract：INTRODUCTION:Major Depressive Disorder (MDD) in accordance to the inflammatory concept is associated with complex immunological disturbances in the central nervous system (CNS). This is reflected by elevated plasma levels of inflammatory cytokines in depressed subjects. Although numerous studies report significant infl...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Więdłocha M,Marcinowicz P,Krupa R,Janoska-Jaździk M,Janus M,Dębowska W,Mosiołek A,Waszkiewicz N,Szulc A

更新日期：2018-01-03 00:00:00

abstract：:A growing body of evidence suggests that inflammation, mitochondrial dysfunction and oxidant-antioxidant imbalance may play a significant role in the development and progression of depression. Elevated levels of reactive oxygen and nitrogen species - a result of oxidant-antioxidant imbalance - may lead to increased da...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Czarny P,Wigner P,Galecki P,Sliwinski T

更新日期：2018-01-03 00:00:00

abstract：:Neuroinflammatory changes have been demonstrated to be an important feature of Alzheimer's disease (AD); however, the exact role of neuroinflammation and its progression during disease is still not well understood. One of the main drivers of the neuroinflammatory process are microglial cells. Positron Emission Tomogra...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Knezevic D,Mizrahi R

更新日期：2018-01-03 00:00:00

abstract：:Neuropsychiatric disorders involve various pathological mechanisms, resulting in neurodegeneration and brain atrophy. Neurodevelopmental processes have shown to be critical for the progression of those disorders, which are based on genetic and epigenetic mechanisms as well as on extrinsic factors. We review here commo...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Corrêa-Velloso JC,Gonçalves MC,Naaldijk Y,Oliveira-Giacomelli Á,Pillat MM,Ulrich H

更新日期：2018-01-03 00:00:00

abstract：:Despite the worldwide use of tramadol, few studies have been conducted about its effects on memory and mitochondrial function, and controversial results have been reported. Recently, there has been an increasing interest in physical exercise as a protective approach to neuronal and cognitive impairments. Therefore, th...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Mehdizadeh H,Pourahmad J,Taghizadeh G,Vousooghi N,Yoonessi A,Naserzadeh P,Behzadfar L,Rouini MR,Sharifzadeh M

更新日期：2017-10-03 00:00:00

abstract：:Emotion regulation by means of cognitive reappraisal has been widely studied with functional magnetic resonance imaging (fMRI). To date, several meta-analyses of studies using cognitive reappraisal tasks in healthy volunteers have been carried out, but no meta-analyses have yet been performed on the fMRI data of clini...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Picó-Pérez M,Radua J,Steward T,Menchón JM,Soriano-Mas C

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:Open and randomized, double blind, placebo-controlled clinical trials have demonstrated clinical efficacy of infrared whole-body hyperthermia in treatment of major depressive disorder (MDD). Demonstration of antidepressant-like behavioral effects of whole-body hyperthermia in preclinical rodent models would ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Hale MW,Lukkes JL,Dady KF,Kelly KJ,Paul ED,Smith DG,Raison CL,Lowry CA

更新日期：2017-10-03 00:00:00

abstract：:Autism spectrum disorder (ASD) gradually develops predominantly neurodevelopmental disorders, which are socially diagnosed in early childhood. Though the etiopathology of ASD is not clear, immune alteration has been suggested as autism's pathophysiological mechanism. Previous studies found that several cytokines and t...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ahmad SF,Nadeem A,Ansari MA,Bakheet SA,Al-Ayadhi LY,Attia SM

更新日期：2017-10-03 00:00:00

abstract：:Repeated exposure to stress during childhood is associated with increased risk for neuropsychiatric illness, substance use disorders and other behavioral problems in adulthood. However, it is not clear how chronic childhood stress can lead to emergence of such a wide range of symptoms and disorders in later life. One ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Watt MJ,Weber MA,Davies SR,Forster GL

更新日期：2017-10-03 00:00:00

abstract：:Inconsistent results have been reported with respect to cardiac autonomic function in major depression. The aim of our study was to investigate autonomic function in various branches of the autonomic nervous system in order to better understand parasympathetic and sympathetic modulation in the disease. We investigated...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Schumann A,Andrack C,Bär KJ

更新日期：2017-10-03 00:00:00

abstract：:Orbitofrontal cortex (OFC) sulcogyral patterns are stable morphological variations established early in life. They consist of three distinct pattern types, with Type III in particular being associated with poor regulatory control (e.g., high sensation seeking and negative emotionality, low constraint), which may confe...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Chye Y,Solowij N,Ganella EP,Suo C,Yücel M,Batalla A,Cousijn J,Goudriaan AE,Martin-Santos R,Whittle S,Bartholomeusz CF,Lorenzetti V

更新日期：2017-10-03 00:00:00

abstract：:The current systematic review study is aimed at critically analyzing from a clinimetric viewpoint the clinical consequence of somatization in Parkinson's Disease (PD). By focusing on the International Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a comprehensive e...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Carrozzino D,Bech P,Patierno C,Onofrj M,Morberg BM,Thomas A,Bonanni L,Fulcheri M

更新日期：2017-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is associated with the progressive aggregation of hyperphosphorylated forms of the microtubule associated protein Tau in the central nervous system. Cotinine, the main metabolite of nicotine, reduced working memory deficits, synaptic loss, and amyloid β peptide aggregation into oligomers and p...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Grizzell JA,Patel S,Barreto GE,Echeverria V

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Several studies have found that depressed, post-menopausal females may respond differently to antidepressants compared to pre-menopausal females. The atypical antipsychotic lurasidone, whose mechanism of action differs from SSRIs and other standard antidepressants, was shown in a 6-week randomized, flexible-...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sramek J,Loebel A,Murphy M,Mao Y,Pikalov A,Cutler NR

更新日期：2017-08-01 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) combined with a cognitive task can enhance targeted aspects of cognitive functioning in clinical populations. The movement disorder Huntington's disease (HD) is associated with progressive cognitive impairment. Deficits in working memory (WM) can be apparent early in the ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Eddy CM,Shapiro K,Clouter A,Hansen PC,Rickards HE

更新日期：2017-07-03 00:00:00

abstract：:The serotonin 1B receptor (5-HT1B) is important to both the pathogenesis of major depressive disorder and the antidepressant effects of selective serotonin reuptake inhibitors. Although fluoxetine has been shown to be effective and safe in children and adolescents, not all patients experience a proper clinical respons...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gassó P,Rodríguez N,Blázquez A,Monteagudo A,Boloc D,Plana MT,Lafuente A,Lázaro L,Arnaiz JA,Mas S

更新日期：2017-04-03 00:00:00

abstract：:A disruption of the oxytocin system seems to affect a variety of brain functions including emotions, mood and social behavior possibly underlying severe social deficits and susceptibility for substance use and mental health disorders. Early life adversity, such as insecure attachment in childhood, has been suggested t...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gerra LM,Gerra G,Mercolini L,Manfredini M,Somaini L,Pieri CM,Antonioni M,Protti M,Ossola P,Marchesi C

更新日期：2017-04-03 00:00:00

abstract：BACKGROUND:Major depressive disorder (MDD) has a high personal and socio-economic burden and >60% of patients fail to achieve remission with the first antidepressant. The biological mechanisms behind antidepressant response are only partially known but genetic factors play a relevant role. A combined predictor across g...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： García-González J,Tansey KE,Hauser J,Henigsberg N,Maier W,Mors O,Placentino A,Rietschel M,Souery D,Žagar T,Czerski PM,Jerman B,Buttenschøn HN,Schulze TG,Zobel A,Farmer A,Aitchison KJ,Craig I,McGuffin P,Giupponi M,

更新日期：2017-04-03 00:00:00

abstract：:Deficiency of omega-3 polyunsaturated fatty acids (PUFAs) and an alteration between the ratio of omega-3 and omega-6 PUFAs may contribute to the pathogenesis of bipolar disorder and unipolar depression. Recent epidemiological studies have also demonstrated an association between the depletion of PUFAs and suicide. Our...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pompili M,Longo L,Dominici G,Serafini G,Lamis DA,Sarris J,Amore M,Girardi P

更新日期：2017-03-06 00:00:00

abstract：:Several environmental factors with periodic changes in intensity during the calendar year have been put forward to explain the increase in suicide frequency during spring and summer. In the current study we investigated the effect of averaged daily sunshine duration of periods with different lengths and 'lags' (i.e. t...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Seregi B,Kapitány B,Maróti-Agóts Á,Rihmer Z,Gonda X,Döme P

更新日期：2017-02-06 00:00:00

abstract：BACKGROUND:Schizophrenia is associated with core emotional dysfunctions. At the neural level, functional neuro-imaging studies have highlighted fronto-limbic alterations during emotion processing in schizophrenia, as well as impaired connectivity between the amygdala and the prefrontal cortex. However, the direction of...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Potvin S,Lungu O,Tikàsz A,Mendrek A

更新日期：2017-01-04 00:00:00

abstract：:Adverse childhood experiences (ACE) can possibly permanently alter the stress response system, affect the glutamatergic system and influence hippocampal volume in mood disorders. The aim of the study is to investigate the association between glutamate levels in the hippocampus, measured through single proton magnetic ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Poletti S,Locatelli C,Falini A,Colombo C,Benedetti F

更新日期：2016-11-03 00:00:00

abstract：:The rate of hippocampal neurogenesis declines with aging. This is partly explained by decreased neural responsiveness to various cues stimulating metabolism. AMP-activated protein kinase (AMPK), a pivotal enzyme regulating energy homeostasis in response to metabolic demands, showed the diminished sensitivity in periph...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Jang S,Kim H,Jeong J,Lee SK,Kim EW,Park M,Kim CH,Lee JE,Namkoong K,Kim E

更新日期：2016-11-03 00:00:00

abstract：:Aggressive behavior is one of the most challenging symptoms in psychiatry, and biological markers for aggression lack of large sample validations. Serotonin (5-HT) and other neuroactive compounds deriving from Tryptophan (Trp), including kynurenine (Kyn), have not yet been investigated in large cohorts of aggressive i...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Comai S,Bertazzo A,Vachon J,Daigle M,Toupin J,Côté G,Turecki G,Gobbi G

更新日期：2016-10-03 00:00:00

abstract：:Our previous studies have shown evidence of endoplasmic reticulum (ER) stress-induced apoptosis in the hippocampus and mPFC in an animal model of post- traumatic stress disorder (PTSD). Inositol-requiring enzyme 1α (IRE1α) and its downstream molecule X-box binding protein 1 (XBP1) play key roles in the ER-related apop...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Zhao W,Han F,Shi Y

更新日期：2016-08-01 00:00:00

abstract：:Monoamine oxidases (MAO) influence the monoamine levels in brain by virtue of their role in neurotransmitter breakdown. MAO B is the predominant form in glial cells and in platelets. MAO B structure, function and kinetics are described as a background for the effect of alterations in its activity on behavior. The need...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ramsay RR

更新日期：2016-08-01 00:00:00